EPAS1 and neuroblastoma: For example, in mouse adipocyte cells the involvement of transcription factors SP1 and SP3 in EPAS1 expression has been suggested [26], while in neuroblastoma cells, phosphatidylinositol 3-kinase (PI3K) and serine/threonine-protein kinase mTORC2 have been demonstrated to regulate its transcription [27].