Contrary to above mentioned VHL interaction proteins, DNA-binding protein inhibitor ID-2 has been reported to be responsible for disrupting the interaction of VHL and HIF2α and increasing the stability of HIF2α in an O2-dependent manner, although ID2 is an oncoprotein and the study was performed in glioblastoma cells [62]. The gene discussed is EPAS1; the disease is glioblastoma.