For 27pepL, the major regulator was TNF, with other effectors such as activated IFNα1/13 and CSF1/2, which can help enhance the antitumor effects of IL-27 in the tumor microenvironment, either by impacting lymphocytes (when connecting to IL15-CD28) or myeloid cells (when connecting to RELA activation). This evidence concerns the gene CD28 and neoplasm.