AURKA, BUB1, CCNB2, CDC20, CDKN3, CENPF, CHEK1, FOXM1, HMMR, MELK, PTTG1, TOP2A, TPX2, TRIP13, TYMS, UBE2C are the hub genes identified in this study that show involvement in the disease-free survival of prostate cancer patients. This evidence concerns the gene CHEK1 and prostate cancer.