The observation from this work which indicates that the expression of genes encoding for microfilaments and intermediate filaments or associated proteins (MYH11, ACTG2, KRT15, NEFH, DES, CNN1, and PCP4) are the most extensively down-regulated in prostate cancer metastasis from all sites suggests fundamental reorganization of their cytoskeleton. This evidence concerns the gene NEFH and Familial prostate cancer.