TGFB1 and hepatocellular carcinoma: The highly expressed postradiation TGFβ cytokine is supposed to have an immunosuppressive function that could be targeted by inhibitors to evoke more effective SRT-induced T cell antitumor activity, as evidenced by the CD8+ cells increase and immunosuppressive T regulatory cells decrease in peripheral blood of SRT-treated patients affected by HCC and administered with a well-tolerated TGFβ-specific blockade (galunisertib) [96].