Sjogren’s syndrome (SS) is an autoimmune disease characterized by autoantibody production (frequently directed against ribonucleoproteins TRIM21/Ro52/SS-A, Ro60, and La/SS-B), destruction of exocrine glands (in particular, salivary and lacrimal) by lymphocytes, and of extraglandular epithelial tissues [57]. This evidence concerns the gene TRIM21 and Sjogren syndrome.