Sjogren’s syndrome (SS) is an autoimmune disease characterized by autoantibody production (frequently directed against ribonucleoproteins TRIM21/Ro52/SS-A, Ro60, and La/SS-B), destruction of exocrine glands (in particular, salivary and lacrimal) by lymphocytes, and of extraglandular epithelial tissues [57]. The gene discussed is TRIM21; the disease is autoimmune disease.