In the current study, we evaluated two universal LAIV prototypes in ferrets, genetically outbred animals, which are considered the best test system for studying influenza in humans, since they have distinct patterns of T-cell reactivity as a result of heterogeneity at the MHC locus, and are also susceptible to infection with virulent influenza viruses with similar to humans manifestation of the disease [8]. This evidence concerns the gene HLA-C and infection.