AR and neoplasm: Although AKT2 (v-akt murine thymoma viral oncogene homolog 2) was down-regulated in all three cancer nodules (x = −1.65 in “A”, −1.61 in “B” and −1.94 in “C”), AR (androgen receptor) was not affected and therefore the tumor did not regress as expected in the androgen-deprivation therapy [65].