However, although in this gene selection, the expression ratio with respect to “N” was the largest for BIRC3 in “C”, it is the down-regulation of KLK3 that had the largest absolute contribution in all cancer nodules (WIR = −585.50 in “A”, −1,248.43 in “B” and −439.17 in “C”) to the transcriptomic alteration in all cancer nodules “B”, owing to its large expression level in the reference tissue (364 in region “N”). The gene discussed is BIRC3; the disease is cancer.