For HBV-related HCC, five genes were recurrently integrated by HBV, including TERT (38.5%, 10/26), MLL4 (11.5%, 3/26), ADAM12 (7.7%, 2/26), PREX2 (7.7%, 2/26), and SCFD2 (7.7%, 2/26) (Table 2). Here, SCFD2 is linked to hepatocellular carcinoma.