Therefore, in order to evaluate the correlation between the CerK/C1P axis and the cachectic/atrophic phenotype, the present study was developed using: (a) mice bearing the C26 adenocarcinoma (C26) or the Lewis lung carcinoma (LLC), well characterized models of cancer cachexia [30,31,32]; (b) myotube cultures treated with conditioned media (CM) obtained from C26- or LLC-cells or with GC [32,33,34,35]. Here, CERK is linked to cancer.