Altogether, these findings indicate that the reduction of CerK expression, observed in tumor-bearing mice and recapitulated in healthy mice by CerK silencing, is associated with the up-regulation of atrogin-1/MAFbx expression and reduced muscle mass, thus confirming the relevance of CerK expression in maintaining a physiological SkM homeostasis. This evidence concerns the gene FBXO32 and neoplasm.