In addition, the contribution of IL-33 to inducing immunosuppressive TME, thus resulting in the conditions in favor of tumorigenesis, has been reported in in vitro and in vivo studies on many cancer types, including colorectal cancer, cervical cancer, gastric cancer, head and neck squamous cell carcinoma (HNSCC), lung cancer, pancreatic cancers [89]. The gene discussed is IL33; the disease is cancer.