In the ApcMin/+ mouse model, IL-33 deficiency decreased the tumor burden [25,138], likely due to, in part, lowered mast cell frequency in polyps and diminished expression of mast cell-derived proteases and cytokines that may facilitate the angiogenesis, MDSC recruitment, and suppressive function of Treg cells [139,140,141]. The gene discussed is IL33; the disease is neoplasm.