CDK4 and familial pancreatic carcinoma: On the other hand, the anti-tumorigenic effects of IL-33/ST2 signaling on inhibiting colon and pancreatic cancer cell growth were observed through autocrine regulation, by the downregulation of pro-proliferative molecules, such as CDK2, CDK4, cyclin B, cyclin D, and by the upregulation of pro-apoptotic molecules, including TRAIL, Bax, or by decreasing Flip and Bcl2 [29,30].