To further elucidate the role of Lrg1 in tumour angiogenesis, future work should compare tumour angiogenesis in Lrg1 knockout mice inoculated with control B16F10 cells, Lrg1 overexpressing B16F10 cells, and B16F10 cells subjected to siRNA-mediated Lrg1 knockdown. This evidence concerns the gene LRG1 and neoplasm.