TP53 and infectious otitis media: To compare the effects of dietary SM in the context of p53 deficiency, wild-type and p53 mutant mice were treated with AOM to investigate the relationship between SM feeding and the tumor suppressor gene p53. The results indicated that a 0.1% SM diet for 4 weeks inhibited cell proliferation but did not induce apoptosis in the distal colon of both types of AOM-treated mice [57].