NFKB1 and rheumatoid arthritis: 7-hydroxyfrullanolide (Figure 7) suppressed the LPS-induced NF-κB-related transcripts in human PMBCs and in freshly collected synovial cells from rheumatoid arthritis patients, by inhibiting the nuclear translocation of NF-κB through the inhibition of IKK phosphorylation in THP-1 cells [64].