SMPDL3A and infection: Franco-Martinez et al. [211] identified a total of 169 proteins in the blood proteome of dogs with leishmanial infection; C8 alpha chain, adiponectin, transferrin, sphingomyelin phosphodiesterase acid-like 3A and immunoglobulins showed different modulation between the stages of the infection and could be considered and further validated for the early diagnosis of the infection.