Molecules with high affinity for PrPSc from brain tissues of sheep were identified [25], whilst in an experimental scrapie model in hamsters, ferritin, calcium/calmodulin-dependent protein kinase a type II, apolipoprotein E and tubulin were identified as the major components associated with the protease-resistant core of PrPTSE (PrP27-30), giving information on the cellular microenvironment of the pathological form of PrP [26]. Here, PRNP is linked to scrapie.