GBM cells secrete immunosuppressive cytokines such as IL-10, transforming growth factor-β (TGF-β), and interleukin (IL)-6, which serve to suppress natural killer (NK) cell activity, suppress T cell activation and proliferation, induce T cell apoptosis, and skew TAMs to an immunosuppressive phenotype [25]. The gene discussed is TGFB1; the disease is glioblastoma.