Basal pADAM17 expression of resting platelets from patients was significantly associated with the extent of pADAM17 downregulation (∆pADAM17: “percent ADAM17 expression in resting platelet”—“percent ADAM17 expression in activated platelet”) upon platelet activation in patients, which was again not observed with platelets derived from HD (p < 0.001, Figure 1D,E). Here, ADAM17 is linked to Huntington disease.