Among these, pioglitazone, a ligand for the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR-γ), and vitamin E, an anti-oxidant agent, have been shown to improve steatosis, inflammation, and ballooning, which are the histological features of NASH/NAFLD [57]. This evidence concerns the gene PPARG and metabolic dysfunction-associated steatotic liver disease.