Consistent with the biochemical and histological features of liver injury, vehicle-treated NASH mice demonstrated significantly increased mRNA of CD36, an uptake transporter for TG, and stearoyl-CoA desaturase-1 (Scd1), a key enzyme in fatty acid (FA) synthesis, and a reduction in microsomal TG transfer protein (Mttp), the transporter necessary for lipid export and assembly of lipoproteins. Here, CD36 is linked to metabolic dysfunction-associated steatohepatitis.