In the present study, three candidate circulating miRNAs (miR-21, miR-27a, and miR-181a) were evaluated as prognostic and predictive factors of response to EGFR-TKI treatment in 39 advanced EGFR-mutated NSCLC patients who underwent EGFR-TKIs. Here, EGFR is linked to non-small cell lung carcinoma.