GWAS of unrelated individuals with AIS have identified potential common risk alleles, notably those in or near LBX1 [9,10,11,12,13,14,15,16,17,18,19,20,21,22,23] and GPR126/ADGRG6 [23,24,25,26,27], which are the most well-replicated genetic findings to date across populations. This evidence concerns the gene ADGRG6 and androgen insensitivity syndrome.