PTH and Marchiafava-Bignami disease: According to the definition contained in a position statement from Kidney Disease: Improving Global Outcomes (KDIGO) [17] chronic kidney disease–mineral and bone disorder (CKD-MBD) is a “systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination of the following: abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism, abnormalities in bone turnover, mineralization, volume, linear growth, or strength; or vascular or other soft tissue calcification”.