The worsening of renal function is associated with the retention of phosphate resulting in hypocalcemia, hyperphosphatemia, and low 1,25(OH)2D3, all promoting parathyroid hormone (PTH) secretion which in consequence leads to increased phosphate excretion and the development of secondary hyperparathyroidism in advanced stages of CKD [1,18]. This evidence concerns the gene PTH and Hypocalcemia.