Taking into account oxidative damage, glutathione depletion, and/or NMDA receptor dysregulation in Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis, high levels of RONS markers (lipid hydroperoxides, MDA, and superoxide dismutase activity—SOD) were found in Parkinson’s disease patients, along with reduced catalase activity. This evidence concerns the gene SOD1 and Parkinson disease.