CD274 and bone metastasis: Based on multivariate Cox analysis, adjusting for cerebral, liver, pleuro-peritoneal and bone metastasis, PDL-1, number of treatment lines and LIPI score, the baseline splenic volume threshold of 194 mL remained significantly associated with OS (HR = 2.6 (1.44; 4.86); p = 0.002) (Table 2).