CD274 and non-small cell lung carcinoma: Patients with metastatic NSCLC have been treated with chemotherapy followed by anti PD-1 mAb in recent years and ICI has become the standard first-line treatment of advanced NS-NSCLC in monotherapy for patients with a high expression of PD-L1 [3,4,5], and is associated with chemotherapy [6] for all comers with NSCLC.