Seventeen somatic mutations in 11 genes (AR, ASXL1, IFG1R, MAP3K13, PDGFRB, PIK3R1, PTPN11, RICTOR, SNCAIP, SPEN, and SUFU) were restrictively detected in captured CTCs, but not in the corresponding tumor samples (Figure 3 and Table 3). Here, SPEN is linked to neoplasm.