TP53 and cancer: Furthermore, in patients’ tumors, several known pathogenic somatic mutations identified in TP53 (c.673-1G>T (rs878854073) in Patient 1; SRC c.7615A>C (rs879255268), TP53 c.827C>G (rs786202082) in Patient 2) are supposedly cancer driver mutations, but they were not detected in CTCs.