AKT1 and colorectal carcinoma: Other studies demonstrated increased expression of e.g., GLUT1, transforming growth factor β1 (TGF-β1), PI3K, Akt, mTOR and Bcl-2 in CRC tissues vs. adjacent normal tissues, with silencing of the GLUT1 gene inhibiting proliferation and promoting apoptosis of CRC cells through inactivation of TGF-β/PI3K/Akt/mTOR signaling [205].