Another panel of cultured CRC cells (HCT116, HT29, LoVo, WiDr, CoLo201, and LS180) showed that glucose causes an increase in expression of GLUT1, amphiregulin (AREG) (member of epidermal growth factor (EGF) family protein), and HIF-1 luciferase reporter promoter. The gene discussed is AREG; the disease is colorectal carcinoma.