Analysis of the whole kinome (779 kinases) siRNA screen, showed an overexpression of 6-phosphofructo-2-kinase fructose-2,6-biphosphatase 3 (PFKFB3), a positive regulator of glycolysis in adipocytes and cancer cells, as a positive regulator of insulin/IGF-1 pathway [67]. Here, IGF1 is linked to cancer.