For instance, Visvanathan et al. developed a panel of 10 genes including RASSF1A, whose methylation index predicted worse PFS (HR: 1.79; CI 95%: 1.23–2.60, and OS (HR: 1.75; 95% CI: 1.21–2.54) in metastatic BrCa patients [147]. Here, RASSF1 is linked to invasive breast carcinoma.