CD274 and lung adenocarcinoma: PD-L1 expression levels were observed to associate with CT radiomic features in two studies (AUC = 0.661 [89] and AUC = 0.848 [88], internal validations), indicating that dense and homogeneous tumors (without ground-glass opacity, necrosis, cavitation or calcification) were more likely PD-L1 positive in lung adenocarcinoma [89].