Firstly, it has been shown that overexpression of CYP24A1 in breast cancer is related to the amplification of chromosomal locus 20q13.2–20q13.3 comprising the CYP24A1 gene, that has been also found in other types of cancer, including colon malignancies [67,82]. This evidence concerns the gene CYP24A1 and digestive system neoplasm.