Vitamin D was reported to block β-catenin-mediated gene transcription in cultured SW480-ADH [175], HT-29 and Caco-2 colon cancer cells [176] by the activation of VDR binding to β-catenin leading to the reduction of the TCF4/β-catenin transcriptional complex formation [175]. Here, VDR is linked to malignant colon neoplasm.