Interestingly, a post hoc analysis of AMATERAS study conducted by Akutsu et al. in which participants were stratified based on p53 protein, vitamin D receptor and Ki-67 expression levels in tumor samples demonstrated that daily 2000 IU vitamin D supplementation significantly improved PFS and a non-significant 10% longer 5-year OS in the subgroup of patients with p53 positive tumors [228]. This evidence concerns the gene TP53 and neoplasm.