CYP24A1 and neoplasm: Moreover, CYP24A1 up-expression is related to poor prognosis in colon, lung and esophageal cancer [68,75,76] The oncogenic role of CYP24A1 is supported by results of studies presented that the suppression of CYP24A1 inhibited tumor growth and strengthened antitumorigenic effects of 1,25(OH)2D3 in breast and lung cancers [77,78,79].