LEP and obesity due to melanocortin 4 receptor deficiency: In accordance, when the frequency of allele G of LEP was correlated with anthropometric and metabolic parameters (e.g., BMI, waist and hip circumference, fasting blood glucose, serum leptin), a greater risk for obesity in both female children and adolescents was noted [25], suggesting that this variant might influence one’s susceptibility to metabolic disturbances and obesity already early on in life.