VEGFA and central nervous system cancer: Wang and colleagues reported that FLA-16 (66), a novel chalcone-type flavonoid isolated from Glycyrrhiza glabra roots, inhibited CYP4A, prolonged the survival and normalized the vasculature of glioma by decreasing the production of tumor-associated macrophages (TAMs) and endothelial progenitor cell (EPC)-derived VEGF and TGF-β in vitro and in vivo [169].