MMP1 and Familial prostate cancer: Ma et al. found that a 3′,5′-diprenylated chalcone (61, Figure 14) likely showed friend leukemia integration-1 (Fli-1) agonism and regulation of the expression of VEGF-1, TGF-β2, intercellular cell adhesion molecule-1 (ICAM-1), p53, and MMP-1 genes, which are associated with tumor apoptosis, migration, and invasion in prostate cancer cells [163].