NFKB1 and cancer: Moreover, Venkateswararao et al. evaluated the inhibitory activity of a series of chalcone derivatives (59, IC50: 1.17–3.43 μM) against NF-κB and their in vitro antiproliferative activity against various human cancer cell lines, and they found a good correlation between NF-κB inhibition through these derivatives and antiproliferative activity [158].