In addition, Saito et al. found that xanthohumol (64), a prenylated chalcone in hops (Humulus lupulus L.), blocked angiogenesis in pancreatic cancer by reducing both NF-κB activity and the subsequent production of angiogenic factors VEGF and IL-8 in vitro and in vivo [167]. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.