Mechanistically, isoliquiritigenin inhibited arachidonic acid (AA) metabolic enzymes, including COX-2, microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11, in glioma and resulted in the inhibition of the angiogenic Akt-FGF-2/TGF-β/VEGF signaling pathway through ceRNA effects on miR-194-5p and lncRNA NEAT1. This evidence concerns the gene AKT1 and central nervous system cancer.