MAPT and early-onset autosomal dominant Alzheimer disease: Both these events are observed in the murine model of Alzheimer’s disease before the amyloid plaques and the neurofibrillary tangles, respectively formed by the two agents known for Alzheimer’s disease agents, A β peptide and hyperphosphorylated tau. Finally, western food, which contains excessive n-6/n-3 ratios, might favor more ARA levels and influence Alzheimer’s disease mechanisms.