Interestingly, analysis of PCa DCC transcriptomes from patients or analysis of PCa PDX models revealed that patients that have no evidence of disease carry DCCs with a signature reflecting TGFβ2 and p38 pathway activation [66,67], while TGFβ2 can also be pro-quiescence for PCa cells [68]. The gene discussed is TGFB2; the disease is posterior cortical atrophy.