To study how SOD3-MSCs can rescue the impaired intestinal epithelium in the context of IBD, we prepared IOs from mice and treated typical proinflammatory cytokines IFN-γ and TNF-α, since these cytokines drive the inflammation-mediated loss of IECs, leading to an IBD-like phenotype [40]. The gene discussed is TNF; the disease is inflammatory bowel disease.