Among the potential related TGA genes, NODAL has emerged (involved in cell differentiation in early embryogenesis) which has been described in familial CHD, and MEGF8 (which encodes a single pass membrane protein, known to participate in developmental regulation and cellular communication) associated with CHD in patients with Carpenter Syndrome subtype associated with lateralization abnormalities of the genetic alterations that cause this pathology. The gene discussed is NODAL; the disease is coronary artery disorder.