GLOD4 and Hyperglycemia: C. elegans (N2, Bristol) glucose-induced hyperglycemia:HCS analysis for AGE accumulation in live animals; quantitative analysis of AGE accumulation by spectrofluorimetry; DNSA method for glucose analysis; semi-quantitative RT-PCR analysis for stress responses genes (glod-4, daf-16, daf-2.)C. elegans TJ356:daf16: GFP:HCS of the localization of daf-16 tagged GFP