In a sense, acquired TTP is caused by an abnormal ratio of vWF, which may be released in normal quantities, and nonfunctioning ADAMTS13, whereas in COVID-19, there is a massive release of ULvWF and regular or reduced levels of ADAMTS13, secondary to consumption, that result in microthrombosis. Here, ADAMTS13 is linked to thrombotic thrombocytopenic purpura.