We aim to evaluate the diagnostic accuracy of ABHD4-regulating RNAs (miRNA-197-5p as a marker of apoptosis; miRNA-221-3p as a marker of inflammatory response, cell adhesion and phospholipid metabolism dysregulation; and FENDRR lncRNA as a marker of myocardial development) for the early detection in patients with unstable angina with troponin level lower than the detection limit and patients who had more than fifty percent coronary artery occlusion. The gene discussed is ABHD4; the disease is angina pectoris.