In several studies, molecules or plant extracts that exhibited inhibitory effects on TARC and MDC induction in TNF-α/IFN-γ-stimulated HaCaT cells also showed anti-inflammatory effects in AD-like mouse models induced by various reagents, such as 2,4-dinitrochlorobenzene (DNCB) or 1-fluoro-2,4-dinitrobenzene (DNFB) [59,60,61]. Here, TNF is linked to Alzheimer disease.