Furthermore, it was found to inhibit Th2 cytokine production and mast cell histamine release by regulating NF-κB signaling in allergic rhinitis [26], and it attenuated the major pathophysiological features of ovalbumin-induced allergic asthma in a mouse model by regulating TGF-β1/Smad signaling pathways [30]. This evidence concerns the gene NFKB1 and allergic rhinitis.