Results indicate that high levels of zinc increase hepatocyte activity and expression of sterol regulatory element-binding transcription factor 1 (SREBP-1), which increase the expression of ACC1, FAS and stearoyl-CoA-1 desaturase (SCD-1) and thereby improve lipid metabolism, while zinc deficiency impairs hepatic lipid metabolism. The gene discussed is SREBF1; the disease is Zinc deficiency.