LEP and obesity due to melanocortin 4 receptor deficiency: In a previous study, after 4 weeks of diet-induced obesity (DIO), low-fat diets with the same percentage of fat calories (9.5% kcal) were given, and experimental oil consisting of 60% MUFAs and P/S = 5 was found to be more effective in reducing the body fat ratio and plasma TC and leptin concentrations, increasing ACO and CPT-1 activities and mRNA expressions and lipid oxidation in the liver, and reducing body fat accumulation in DIO hamsters compared to those fed soybean oil [18].