Once again, the only exception to this general observation was the combined blockade of the functions of CTLA-4 and PD-1 immune checkpoints which, when added to the WBIs, exerted a notably more pronounced effect both in vivo (growth of the tumors in the lungs and under the skin) and in vitro (clonogenic potential of the tumor cells). This evidence concerns the gene CTLA4 and neoplasm.