PRSS56 and Leber congenital amaurosis: Among others, genes regulating processes in neurotransmission like histidine decarboxylase (Hdc); galactosidase beta 1 like 3 (Glb1l3), which is associated with Leber’s congenital amaurosis; as well as serine protease 56 (Prss56), which was reported to be involved in eye development, were significantly downregulated.