AVPR2 and cancer: Interestingly, the inhibition of tumor growth by MTF was hampered in cells expressing a MTF-resistant yeast analogue of Complex I (NDI1), suggesting that inhibition of Complex I is an important mechanism of the action of MTF, also against cancer [21,25]; in fact, MTF was shown to reduce the aerobic ATP production in many cancer cells [26], although its effect seems to depend on tumor adaptive strategies, cancer stem cell selection, tumors metabolism, and microenvironment [27].