Transplantation of embryonic BAT with IGF-1 supplementation in type 1 diabetic (T1D) adult mice was able to successfully correct T1D phenotypes, producing rapid and long-lasting normoglycemia, independent from insulin, at a 57% success rate [135], another outstanding example of the beneficial effects of activated BAT on diabetes. The gene discussed is INS; the disease is type 1 diabetes mellitus.