This study aimed to explore the association of the ENPP1 K121Q (rs1044498) SNP with insulin resistance, and the ADIPOQ + 267G > T (rs1501299) SNP with circulating adiponectin levels in a case–control study involving 110 (55 obese and 55 lean individuals) Javanese people residing in Yogyakarta, Indonesia. Here, ADIPOQ is linked to Insulin resistance.