We already pointed that AnxA1 is an endogenous PLA2 inhibitor that can be cleaved by different proteases, including elastase, calpain, plasmin, proteinase 3, and Cathepsin D. Of particular interest is the cleavage of AnxA1 by the soluble lysosomal aspartic endopeptidase (EC 3.4.23.5), Cathepsin D, which is found to be highly expressed in various types of cancers and correlated with metastasis [190]. The gene discussed is CTSD; the disease is cancer.