Further, it has been reported that the VHSV Nv protein negatively regulated host antiviral response by reducing the transcription factor NF-kappa-B activator (tank)-binding kinase 1 (tbki) phosphorylation, and therefore preventing the activation of interferon regulatory factor 3 (irf3) and the induction of type I IFN response following viral infection [20]. The gene discussed is IRF3; the disease is viral infectious disease.