PTEN and cancer: Microwestern array showed downregulation of the proapoptotic marker BAX along with the cancer suppressor genes PTEN and GSK3β; however, western blotting results show upregulation of signaling PI3K p85, Phospho-PI3K p85 (Tyr458), Phospho-AKT (Ser473), Phospho-GSK3β (Ser9), and Phospho-S6 (Ser235/236) were upregulated in DEHP-exposed clones, which supports the finding that PI3K/Akt was activated.