FGF2 and neoplasm: Shee et al. [48] recently published a study stating that factors secreted by the TME, mainly the angiogenic cytokine fibroblast growth factor 2 (FGF2), which promotes tumour progression via irregular vascular formation, was highly overexpressed within ER+ breast cancer cells after in vivo experiments of immunocompromised mice bearing MCF-7 xenografts.