Since constitutive activation of mTORC1 alters several aspects of cell metabolism including increasing aerobic glycolysis [45,46], and we showed that loss of Tsc1 in PRs of wild-type mice leads to AMD-like pathologies [14], we asked whether changes in aerobic glycolysis that could affect the retinal-RPE metabolic ecosystem underlie the development of these pathologies. This evidence concerns the gene TSC1 and age-related macular degeneration.