Unexpectedly, octogenarians’ breast cancer was not associated with any gene set associated with cancer aggressiveness, such as angiogenesis, epithelial–mesenchymal transition, KRAS signaling pathway, PI3K-AKT signaling pathway, MYC targets, or mitotic spindle in either the TCGA or the METABRIC cohort (Figure 4, showing only results for TCGA). This evidence concerns the gene MYC and breast cancer.