Unexpectedly, octogenarians’ breast cancer was not associated with any gene set associated with cancer aggressiveness, such as angiogenesis, epithelial–mesenchymal transition, KRAS signaling pathway, PI3K-AKT signaling pathway, MYC targets, or mitotic spindle in either the TCGA or the METABRIC cohort (Figure 4, showing only results for TCGA). The gene discussed is AKT1; the disease is cancer.